The discovery of RNA interference(RNAi)has changed people’s traditional concepts of the gene.This technique posseses advantages and potentials that traditional therapies can not compare especially in terms of its specificity and efficiency,and it is drawing more and more attentions from ophthalmologists all over the world these year. Although there are still a lot of problems in clinical use at present,various kinds of related experimental results make us firmly believe that RNAi will surely bring a new epoch for curing diseases in ophthalmology.This article provides an overview on some of the latest advances in fundus.