Optic neuritis(ON) is a kind of optic neuropathy which can obstruct the conduction of optic nerve and result in a series of changes in visual functions. The main treatment of the ON is the medication,especially, the application of glucocorticosteroid in a combined therapy. The present paper summarized the recent advance of medicines which had been used in ophthalmologic clinic, including glucocorticosteroid, antiviral drugs and other medicines.