AIM: To evaluate the curative effect of Nd∶YAG laser photocoagulation in the treatment of retinal vein occlusion(RVO). METHODS: Forty-two eyes of 42 patients diagnosed as RVO by fundus fluorescein angiography(FFA) were photocoagulated by frequency-doubled Nd∶YAG laser. Different methods were applied for different types, the visual acuity were compared and fundus changes were observed by FFA after photocoagulation. RESULTS: The visual acuity of 4 eyes (10%) improved after treatment;30 eyes (71%) remained the same;8 eyes’(19%) visual acuity decreased. It was effective in 38 eyes of the patients treated with Nd∶YAG laser photoco- agulation showed by FFA, the efficiency rate was 90%. CONCLUSION: Frequency-doubled Nd∶YAG laser photo- coagulation is effective in the treatment of RVO. It not only helps the absorption of retinal edema, hemorrhage and exudation, but also prevents the occurrence of proliferative vitreoretinopathy or neovascular glaucoma.