AIM: To evaluate the efficacy of soft shell technique with Sodium Tvlose and sodium hyaluronate during cataract phacoemulsification with intraocular lens(IOL) implantation. METHODS: Eighty two eyes of 76 patients with mature cataract underwent phacoemulsification with IOL implantation, including 41 eyes using the soft shell technique with Sodium Tvlose and sodium hyaluronate(study group). RESULTS:The average naked vision was 0.50±0.22, 0 51±0.27 respectively the first day after operation, the difference between the study group and control group was not statistically significant, The average naked vision was 0.61±0.17, 0.63±0.18 respectively seven days after operation, there was no statistically significant difference between the two groups. The loss rate of corneal endothelial cells 1 month after surgery was 7.1% in the study group, 6.9% in the control group. There was no statistically significant difference between the two groups. CONCLUSION: The soft shell technique with Sodium Tvlose and sodium hyaluronate is the same safe and effective in protecting corneal endothelial cells during cataract surgery in patients with mature cataract as the import material.