·AIM:To investigate the efficacy of photodynamic therapy(PDT)and injection of triamcinolone acetonide(TA)via posterior sub-tenon combination therapy on choroidal neovascularization(CNV)combined with multifocal choroiditis(MC).·METHODS:Eight patients(8 eyes)who were diagnosed as MC combined with CNV were retrospectively analyzed.The changes in the best-corrected visual acuity(BCVA),FFA/ICGA and OCT were analyzed before and after combination therapy.·RESULTS:During 6-month follow-up the BCVA was improved after combination therapy(P<0.05).FFA/ICGA showed decrease and stoppage of inflammation on preocular and fundus in 8 eyes(100%),no leakage or reduced leakage in 7 eyes(88%)1 month after combina-tion therapy.In 1 eye(12%),the fundus remained leaky.At the 6-month follow-up,no inflammation relapse was obtained,FFA /ICGA showed no leakage or slight leakage in 8 eyes(100%).·CONCLUSION:Combination therapy of PDT and injec-tion of TA via posterior sub-tenon is safe and effective to CNV combined with MC.·