AIM:To investigate the application of vitrectomy combined with the ultrasonication of crystalline lens in ocular injury with lens dislocation.·METHODS: The data of 40 cases 40 eyes with ocular injury with lens dislocation treated by different ways of surgery in our Eye Center for 2 years were selected, and the complication after surgery, sight after surgery, intraocular tension, and so on were analyzed. The follow-up period was 3 months to 2 years.·RESULTS:In 19 cases 19 eyes with "vitrectomy com-bined with lens removal through limbus of cornea", corrected vision of 1 case 1 eye was not improved due to optic nerve contusion and it was not implanted intraocular lens. The rest 18 cases 18 eyes were all implanted posterior chamber intraocular lens, in which 8 cases 8 eyes had significant therapeutic effect accounted for 44%, 5 cases 5 eyes had therapeutic effect, accounted for 28%, 5 cases 5 eyes was ineffective, 28%. In 21 cases 21 eyes with "vitrectomy combined with the ultrasonication of crystalline lens ", corrected vision of 2 cases 2 eyes were not improve due to optic nerve contusion and they were not implanted intraocular lens. The rest 19 cases 19 eyes, were all implanted posterior chamber intraocular lens, in which 16 cases 16 eyes had significant therapeutic effect, accounted for 84%, 2 cases 2 eyes had therapeutic effect, accounted for 11%, 1 case 1 eye was ineffective, accounted for 5.26%. The comparison of significant therapeutic effect between two groups had statistical significance(χ2=4.787,df=1,P=0.029<0.05),No complications occurred. 5 cases 5 eyes complicated retina damage, accounted 26.32% in "vitrectomy combined with lens removal through limbus of cornea", and the comparison accounted for between two groups had statistical significance(χ2=4.193,P=0.042<0.05). 3 cases 3 eyes complicated with the interior of eyeball hemorrhage, accounted for 15.79%,and the comparison between two groups had no statistical significance.·CONCLUSION: The eyeballs of patients with ocular injury with lens dislocation can be operated under the airtight condition by "vitrectomy combined with the ultrasonication of crystalline lens ", which make the damage of eyeball tissue further reduced.Thereby, patient’s sight is remedied and improved in a very large extent.