AIM:To evaluate the changes of corneal topography and corneal astigmatism after pterygium excision with two different surgical methods.METHODS:Twenty-three eyes of 20 patients with primary pterygium were selected and separated into 2 groups randomly as follows:group A,pterygium excision with 0.2g/L mitomycin C(MMC) for 2 minutes intrao-peratively for 11 patients 13 eyes;group B,pterygium excision with autografting limbus stem cells trans-plantation for 9 patients 10 eyes.The changes of corneal topography and corneal astigmatism were observed by the OrbscanⅡ Corneal Topography System before the surgery and 1 week,1 month after surgery respectively.RESULTS:In both two groups,significant decreases in the results of the anterior surface of the cornea to the perfect spherical surface(Diff value),corneal curvature,and corneal astigmatism were seen after 1 week and 1 month follow-up,and the differences had statistical significances(P<0.05).In group A,the changes of those values above between postoperative and preoperative were more apparent than those in group B in statistics(P<0.05),while the posterior surface of the cornea to the perfect spherical surface(Diff value) on 1 week and 1 month after surgery had no statistical difference between two groups.And the changes of the posterior surface of the cornea to the perfect spherical surface(Diff value) between postoperative and preoperative had no statistical differences.CONCLUSION:Surgical excision combind using 0.2g/L MMC intraoperatively can release the mechanical force on cornea by pterygium,and improve topographic and clinical astigmatism significantly.This combined surgical method is efficient,it can reduce the pterygium recurrence,decrease the corneal astigmatism,and improve visual acuity as well.