AIM:To explore the safety and effectiveness of 532nm laser + Nd:YAG laser in peripheral iridectomy treatment for early pupil closure glaucoma.METHODS:Fifty-six cases of pupil closure glaucoma who complied with the standards were selected and numbered randomly,and then devided into group A and B,group A(28 cases)took ND:YAG laser,group B (28 cases) took 532nm laser +ND:YAG laser treatment.The results of visual acuity,intraocular pressure (IOP),laser hole,vision and a cornerstone were observed,and the key observation was IOP control.RESULTS:After two years of clinical follow-up,IOP:(28.32±3.43)mmHg for group A before the operation,and (24.82±3.27)mmHg after the operation,using matching t-test(tA=3.256,P>0.05),the results had no statistically significant differences,IOP control for group A was not ideal;(28.79±3.63)mmHg for group B before the operation,and (15.31±3.18)mmHg after the operation,using matching t-test (tB=26.315,P<0.05),the results had statistically significant differences,the results of laser treatment for IOP control on group A and B,the difference was statistically significant (χ2= 42.23,P<0.05).Vision:by t-test,group A:tA=2.375,group B:tB=2.362.Neither the vision changes for group A and B nor the difference between group A and B had statistical significance(χ2=3.845).Complications:neither group A nor B had serious complications.CONCLUSION:532nm laser + ND:YAG laser treatment is a safe and effective method for peripheral iridectomy on early pupil closure glaucoma,it could significantly reduce IOP,preserve the visual function.