AIM:To observe the efficacy of pterygium microsurgery and mitomycin C in pterygium patients.METHODS:All the operation procedure was under the operating microscope:after local anesthesia,conjunctiva was cut outside the 1mm of limbus with corneal scissors,conjunctival and pterygium tissue were isolated,and the proliferation of pterygium was cut off,hypertrophy conjunctival tissue,and residual pterygium in the cornea and sclera were cleared off.After that,cotton pad with 0.2g/L mitomycin C solution was placed on the surface of the sclera ablation area for 3 minutes,fixed conjunctival flap was sutured to the sclera and the cornea,limbus and sclera was exposed (3-4mm).After that,the eyes drops of compound neomycin sulfate was used q.i.d.for 2 weeks.RESULTS:The follow-up was 3-48 months,the number of continual days of corneal irritation after surgery was reduced in all out-patients.The visual acuity was improved in 39.2% of patients and the recurrence rate was 3.9%.CONCLUSION:Pterygium microsurgery and 0.2g/L mitomycin C application is a method of low recurrence rate and mild reaction.