·AIM:To analyze the drug toxicity of tobramycin dexamethasone eye drops in ocular surface and to investigate the clinical features,treatment effect of dexamethasone-induced drug-induced corneal lesions.·METHODS:The clinical findings in 14 cases 18 eyes with tobramycin dexamethasone-induced drug-induced corneal lesions after cataract surgery were retrospectively analyzed.·RESULTS:Tobramycin dexamethasone eye drops were used in 14 patients 18 eyes for more than 1 week;clinical manifestations:eye irritation:eye wear,tearing,photophobia,decreased vision.Signs:ocular ciliary hyperemia and punctate corneal erosion in 11 eyes,diffuse corneal opacity in 6 eyes,corneal stromal infiltration in 1 eye.Patients with a history of diabetes mellitus in 5 eyes,anti-glaucoma surgery in 6 eyes,2 eyes after vitrectomy,the body in good condition in 5 eyes,after drug withdrawl,eye symptoms relieved,disappeared.·CONCLUSION:Clinicians should pay attention to the toxity of tobramycin dexamethasone eye drops on cornea,and prevention and treatment,standard medication should be performed.·