· AIM:To observe the clinical application of carbamycholine in the trabeculectomy combined with cataract phacoemulsification and intraocular lens implantation.· METHODS:Ninety-seven patients 120 eyes with chronic angle-closure glaucoma with age-related cataract from January 2007 to January 2008 were randomly divided into three groups:the observation group(group A,conjunctival sac carbamycholine dropping after phacoemulsification),the replacement group(group B,the anterior chamber carbamycholine replacement after phacoemulsification)and the retention group(group C,the anterior chamber carbamycholine detain after phacoemulsification).Intraocular pressure(IOP)vision,anterior chamber exudation,iris weeks incision and complications in each group(40 eyes,aged 60-80 years old,followed-up for 12 months)were observed.· RESULTS:Early IOP control of A,B group was significantly better than that of C group;and the difference was statistically significant(P<0.05),but later IOP control among the three groups showed no significant difference;early visual acuity of A,B group was significantly better than that of C group,the difference was statistically significant(P<0.05),but later visual acuity showed no significant difference;the moderate rate of iris incision size among the three groups showed no significant difference;the anterior chamber exudation of group A was lower than that of B,C group,the difference among the three groups was significant(P<0.05).· CONCLUSION:Carbamycholine application in glaucoma with cataract surgery can increase postoperative response,while reasonable application can significantly reduce its side effects.·