脉络膜再血管化术联合药物综合治疗视网膜色素变性
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R774.1

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Choroid revascularizaton surgery associated with medicine treatment for primary pigmentary degeneration of retina
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    目的:探讨治疗原发性视网膜色素变性的有效方法。方法:选择符合诊断及入选标准的原发性视网膜色素变性患者60例120眼,采用脉络膜再血管化术联合药物综合治疗,12mo后观察患者视力、视野、视网膜电图(ERG)。结果:患者60例120眼中,视力下降者2眼(1.6%),视力无提高者15眼(12.5%),视力提高0.02~0.20者80眼(66.7%),视力提高>0.20者23眼(19.2%)。56例112眼做了周边视野(60°)和中心视野(30°)检查,治疗前45眼可检测到周边视野敏感度,治疗后56眼可检测到,检出率为50%,56眼经过12mo观察后,其中47眼周边视野和中心视野无变化,有效率为83.9%。59例患者110眼行ERG检查(8眼初期未见异常,未作检查),治疗前100眼记录不到a波与b波,治疗前后无变化。30Hz闪烁反应治疗前59例患者110眼中54例97眼可记录到波形,检出率为88.2%;治疗后100眼可记录到波形,检出率为90.9%。结论:脉络膜再血管化术联合药物综合治疗能延缓或控制原发性视网膜色素变性病情发展,提升视力,改善视功能,值得临床推广应用。

    Abstract:

    ·AIM:To investigate an effective treatment for primary pigmentary degeneration of retina.·METHODS:Totally 60 cases 120 eyes enrolled by standard diagnosis underwent choroids revascularization surgery associated with medicine treatment.After 24-36 months,we observed visual acuity,visual field,electroretinogram(ERG).·RESULTS:There was decrease of vision acuity in 2 eyes(1.6%),no improvement in 15 eyes(12.5%),improvement ranged from 0.02 to 0.20 in 80 eyes(66.7%),over 0.20 in 23 eyes(19.2%).The examination of peripheral fields(60°)and central visual field(30°)was performed on 56 cases 112 eyes.The sensitivity of peripheral fields could be detected in 56 eyes after the treatment(50%),whereas only in 45 eyes,and no changes in 47 eyes before the treatment.The detection rate was 83.9%.ERG was done in 59 cases 110 eyes.Wave a and wave b could not be recorded in 100 eyes before or after the treatment;wave shape could be recorded in 100 eyes after the treatment with a detection rate of 90.9%.·CONCLUSION:Choroid revascularization surgery associated with medicine treatment can control the development of primary pigmentary degeneration of retina and improve visual acuity and visual function.·

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刘雪芳,惠晓颖,朱赛林.脉络膜再血管化术联合药物综合治疗视网膜色素变性.国际眼科杂志, 2010,10(8):1554-1555.

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