·AIM:To observe the clinical effects and complications of orthokeratology lens for myopia,and to analyze the relevant factors.·METHODS:The medical records of orthokeratology lens wearer 302 cases 601 eyes from three eye centers were analyed and the uncorrected visual acuity,refractive status,Orbscan examination,fluorescein staining 1 week;1 month,3 months after wearing glasses were observed.The condition of all patients before treatment was regarded as control group.·RESULTS:There was significant difference 1 week;1 month,3 months after wearing glasses compared with before wearing glasses in uncorrected visual acuity(t=-95.920,-77.710,-65.362;P<0.01,<0.01,<0.01),the anterior corneal surface horizontal curvature(t=26.020,20.143,17.476;P<0.01,<0.01,<0.01)and there was significant difference 1 week,1 month,3,6 months after wearing glasses compared with before wearing glasses in the anterior corneal surface perpendicular curvature(t=22.505,20.626,21.667,25.397;P<0.01,<0.01,<0.01,<0.01);However,There were no significant difference in uncorrected visual acuity 1 week;1 month,3 months after wearing glasses compared with the corrected visual acuity before wearing glasses.(t=-1.364,0.599,0.581;P=0.174,0.550,0.562);The punctate loss of corneal epithelium and indentation of center cornea appeared in 1 week was 7.5%,1 month 6%,3 months 9.8%,of which recurrence ratio was 2.5%.·CONCLUSION:Orthokeratology has the quick,effective,safe,and reversible advantages for myopia,whereas it has certain applicability for correction of myopia.·