·AIM:To investigate the effects of amniotic membrane transplantation on persistent corneal epithelial defects.·METHODS:Amniotic membrane transplantation was performed on 15 cases caused by various reasons.All patients were followed up for 18 months and examined with slit-lamp and fluorescein staining.·RESULTS:All patients healed completely in three weeks with smooth corneal surface.The vision of 10 cases was improved.·CONCLUSION:The transplantation of amniotic membrane is an efficient method for persistent corneal epithelial defects.·