AIM:To investigate the value of sera FT3,FT4,TSH,TPOAb in exophthalmos patients with Graves’ disease(GD);and to summarize and analyze the topography of the clinical manifestation of GD,such as exophthalmos,lid retraction and lid fullness,hypophasis,hyperremia and edema of conjunctiva,disorder of ocular movement and so on. ·METHODS:The clinical manifestations of 207 patients with GD who underwent radioiodine therapy were collected and analyzed,and sera FT3,FT4,TSH,TPOAb levels were measured and compared in patients with GD and exophthalmos (n=125) and GD patients(n=82). ·RESULTS:Exophthalmos were present in 125 cases (60.4%);lid retraction in 169 cases (81.6%);hypophasis in 176 cases(85.0%),lid fullness in 88 cases (42.5%);hyperremia and edema of conjunctiva in 92 cases(44.4%);disorder of ocular movement in 16 cases(7.7%); corneal edema or ulcer in 3 cases(1.4%);sera FT3,FT4,TSH,TPOAb levels in two groups had no significant difference(P>0.05). ·CONCLUSION:Both groups are all in high secretor state; different ocular manifestations are present in over 85% patients. Diagnosis and treatment of thyroid-associated ophthalmopathy(TAO) can’t be ignored.