AIM:To investigate the outcome and treatment parameter of transscleral diode laser cyclophotocoagula-tion in refractory glaucoma. ·METHODS:Fifty patients 50 eyes of refractory glaucoma were treated with the transscleral diode laser cyclo-photocoagulation,the power,area,points of photocoa-gulation,points of blast were recorded,intraocutar pressure(IOP),symptom,visual acuity,the representa-tion of anterior segment before and after treatment and the complication were observed. ·RESULTS:The average of IOP was 18.50±2.50mmHg after treatment,obviously decreased after treatment (P<0.01). The pain decreased in 46 eyes,the decreasing amount of IOP was not obviously correlated with power,but had relativity with area and points of cyclo-photocoagulation,and had obvious positive relativity with points of blast. ·CONCLUSION:It is a safe and effective method to treat the refractory glaucoma with transscleral diode laser cyclophotocoagulation; and it is important to design the treatment parameter acording to the IOP before treatment and different type glaucoma.