AIM:To evaluate the effect of limbal stem cell autograft transplantation combined with mitomycin C in the treat-ment of pterygium. ·METHODS:Totally 258 cases 272 eyes patients of newly developed pterygium (229 eyes) and recurrent pterygium (43 eyes) were performed limbal stem cell autograft transplantation combined with mitomycin C. The postoperative follow-up period ranged from 12 to 24 months. ·RESULTS:Fourteen eyes of newly developed pterygium and 3 eyes of recurrent pterygium (6.3%) were recurred. ·CONCLUSION:The method of limbal stem cell autograft transplantation combined with mitomycin C drops can reduce the recurernce rate.