AIM:To explore the clinical characteristics of ocular cicatricial pemphigoid,and provide assistance in clinical diagnosis and therapy. ·METHODS:The data of 35 cases of ocular cicatricial pemphcgoid from January,2002 to January,2008 was retrospectively analyzed. ·RESULTS:The average age of ocular cicatricial pemphigoid was 62.4 years,and the rate of male and female gender was 20/15. The average history was 3.3 years. The oral mucosa was firstly invaded in 51.43% patients,ocular mucosa in 31.43% ones,and other mucosa in 17.14% ones. In eye-involved patients,the rate of eyelid entropium and trichiasis,dry eye and chronic conjunctivitis,and corneopathy was 5/4/2. After treatment,71.43%(25/35) cases were cured,while 14.29% (5/35)cases were not cured,and 14.29%(5/35)cases did not accomplished the regimen. In the course of treatment,the complications were found in 37.14% (13/35)cases,and among these,abnormal liver function was found in 6 cases and 2 cases withdrew from treatment,abnormal kidney function in 2 cases and 1 case discontinued the protocal,abnormal blood system in 3 cases and 1 case quitted the regimen,myocardial infarction in 1 case who gave up the treatment,and apparent blood hypertension in 1 case. ·CONCLUSION:Cicatricial pemphigoid is a chronic ailment and often involved in the elderly. Male patients are more than female ones,and ocular tissue is often involved. Dry eye disease,symblepharon,entropion and trichisis are all its manifestations. The treatment of cicatricial pemphigoid is complicated,and multidisciplinary collaboration is required.