AIM:To determine the efficacy and safety of intravitreal triamcinolone acetonide(TA) combined with laser photocoagulation in macular edema caused by retinal vein occlusion. METHODS:Thirty-eight macular edema eyes of 38 patients with retinal vein occlusion were diagnosed by ophthalmoscopy,FFA and OCT.All patients received an intravitreal injection of 4mg of TA(0.1mL) and photocoagulation after 1-2 month(s).The changes of vision,ocular tension,ocular fundus and retinal thickness were observed for 3-9months. RESULTS:Visual acuity was improved in 36 eyes, remained stable in 2 eyes.Visual acuity less than 0.1 were in 3 eyes,0.1-0.3 in 11 eyes,0.3-0.5 in 17 eyes,more than 0.5 in 7eyes.Ocular tension increased in 4 cases in different extent and put back in 2-5 months after given ocular hypotensive agents.No one occurred retinal toxic reaction. CONCLUSION:Intravitreal TA combined with laser photocoagulation is an efficient and safe treatment in macular edema caused by retinal vein occlusion,it can improve the visual acuity remarkablely.