AIM:To compare the clinical effects of amblyopia combined training with rigid gas permeable contact lens (RGP)and frame glasses. METHODS:A total of 106 patients(including 189 eyes) were enrolled in this study.They were randomly divided into Group A(53 cases 99 eyes) wearing RGP and group B(53 cases 90 eyes) wearing frame glasses.Then the two groups received the same combined training to treat amblyopia 1 month after wearing glasses and the conditions of sight were observed 3,6 months and 1 year after wearing glasses. RESULTS:It was safe and effective to wear RGP, without occurrence of such severe complications as acute conjunctivitis or keratitis.The recovery rate of amblyopia in group A was significantly higher than that of group B, especially in treating patients with high anisometropia. There existed significant difference in Ridit test(P<0.05).After wearing RGP for 1 month in group A,5 patients 7 eyes had the corrected vision>0.8 without amblyopia training. CONCLUSION:Wearing RGP is better than wearing frame glasses in visual quality,and is a safe and effective tool to treat anisometropic amblyopia,which is worth to generalizing.