AIM:To investigate the causes,treatment and prevention of scleral melt after pterygium excision. METHODS:Totally 14 patients underwent pterygium excision alone,of which 11 cases use of MMC intraoperatively. The hormone eye drops wasn’t applied according to the condition of scleral melt.Non-hormonal antibiotic eye drops,bFGF eye drops combined with calf blood protein eye gel,subconjunctival injection of tobramycin + VitC and pressure dressing were applied.All the results were reviewed and analyzed. RESULTS:All patients were treated with drug,and the sclera kept the smooth surface. CONCLUSION:Scleral melt after pterygium surgery is correlated with surgical methods,surgical techniques, intraoperative and postoperative medication and patient physical factors.Scleral melt after inappropriate handling or excision should be understood.