AIM:To evaluate the recurrence rate and safety of amniotic membrane transplantation (AMT) augmented with mitomycin C (MMC) compared with amniotic membrane transplantation alone during the pterygium excision. ·METHODS:We took a meta-analysis on this program. Pertinent studies were selected through extensive searches of the Cochrane Library,MEDLINE,EMBASE,CBMdisc,CNKI. Pooled estimates were carried out in RevMan software V4.2. ·RESULTS:Six trials reported postoperative recurrence rate of pterygium,included 882 eyes,three trials reported the complications. The results of meta-analysis showed that recurrence rate of AMT plus MMC group was 5.41%,AMT alone group was 16.89%,relative risk(RR) was 0.32,95%CI ranged from 0.19 to 0.56,Z was 4.06,P<0.001. Two trials reported early complication as punctata keratitis,the incidence rate of AMT plus MMC group and AMT alone group were 17.14% and 0.00%,RR was 12.11,95%CI ranged from 1.62 to 90.76. ·CONCLUSION:Amniotic membrane transplantation with MMC is associated with lower recurrence rate compared with amniotic membrane transplantation alone in pterygium excision,whether accompanied a higher risk with adverse events need more investigation.