AIM:To evaluate the clinical manifestations and visual outcome of syphilitic uveitis patients.·METHODS:Case series of three patients with syphilitic uveitis were managed in Hospital USM.·RESULTS:Three patients were diagnosed to have uveitis secondary to syphilis. All three patients were not known to have syphilis prior to presentation but had positive history of sexual promiscuity. All patients presented with progressive blurring of vision for average of one-month duration. Two of them had association with fever,ocular pain and floaters. Visual acuity at presentation ranged from 6/12 to hand movement. Mild anterior uveitis (non-granulomatous),vitritis and papillitis were present in all the patients. First patient had multifocal chorioretinitis with exudative retinal detachment. The second patient presented with exudative retinal detachment while the third patient had chorioretinitis only. All the patients were treated with intramuscular benzyl-penicillin 2.4 MU weekly for 4 weeks and two of them received oral doxycycline 200mg twice daily for 3 months. The uveitis responded well to the treatment and two of them showed dramatic visual improvement from 6/120 to 6/21 and 6/12 to 6/6. The one with worse outcome was confirmed to have positive retroviral.·CONCLUSION:Ocular syphilis presented here as non-granulomatous inflammation associated with exudative retinal detachment. Final visual outcome is generally good despite slow improvement after treatment.