AIM:To evaluate the clinical efficacy and safety of three methods for eyelid xanthelasma.·METHODS:Totally 66 cases 132 eyes of eyelid xanthelasma were equally divided into 3 groups by different treatment methods:group A (n=22) was treated with heparin sodium; group B (n=22) was treated with conventional surgery; group C (n=22) was treated with comprehensive therapy (invasive drug and lipid-lowering).·RESULTS:The total effective rate was significantly better in group C than that in group A and group B. There was no significant difference in adverse effect among the three groups.·CONCLUSION:The comprehensive therapy including invasive drugs and oral lipid-lowering drugs is a safe and effective,convenient and low recurrence rate method for eyelid xanthelasma,which is worth promoting.