AIM:To evaluate the clinical curative effect of compreherisive treatment for children’s anisometropic amblyopia.·METHODS:Totally 48 children of anisometropic amblyopia from January 2005 to January 2010 were included in this study. The patients were randomly divided into two groups. The experimental group had 24 cases,which were treated with compreherisive therapy. The control group had 24 cases,which were treated with correction of refractive errors and occlusion therapy. The recovery of the vision and the stereoscopic vision were observed.·RESULTS:The curative effect were compared between the experimental group and the control group,and the difference had statistical significance(P=0.007);compared with the control group,the effect aprearance time was significant reduced in the experimental group (P=0.005);the recovery situation of the stereoscopic vision was compared between these both groups,and the difference had statistical significance(P=0.022).·CONCLUSION:The clinical curative effect of comprehensive treatment on anisometropic amblyopia of children is affirmative,and the curative effect appearance is short with better recovery of the stereoscopic vision.