AIM:To study deep sclera and Descemetic membrane incision with anterior air for glaucoma and refractory neovascular glaucoma.METHODS:Deep sclera and Descemetic membrane incision was performed in 111 eyes of 102 patients with glaucoma and refractory neovascular glaucoma.RESULTS:Follow-up period ranged from 18 to 36(mean 21.5)months.The mean IOP decreased significantly after operoction.The functional bulb forming was seen in glaucoma(95.5%)after operation.The mean visual acuity significantly changed before and after operation(P<0.05).No severe intraoperative and postoperative complications were found.CONCLUSION:A safe and effective result is observed in the deep sclera and Descemetic membrane incision with anterior air in the treatment of various glaucoma.