AIM:To compare clinical effects of cataract with high myopia patients implanted three different kinds of intraocular lens(IOL).METHODS:Sixty-eight cataract with high myopia eyes undertook phacoemulsification and IOL implantation,including three different kinds of IOL.1-piece hydrophilic acrylic IOL(Bigbag,Zeiss);1-piece hydrophilic acrylic IOL(620H,Rayner);and 1-piece hydrophilic acrylic IOL(HQ201-hep).Anterior chamber depth after mydriasis,tilt and deviation of IOL were measured using Scheimpflug system(Pentacam,Oculus) and analyzed with Image-pro plus 6.0 software.RESULTS:Comparison of the anterior chamber deepth among the three groups was statistically significant(F=50.74,P<0.05).Difference between postoperative actual refraction and target refraction was not statistically significant(F=1.391,P>0.05).Deviation and tilt of IOL among the three groups showed no statistical significance(P>0.05).No eyes were detected posterior capsule opacification,macula edema and retinal detachment.CONCLUSION:Three different kinds of IOL can be implanted for cataract patients with high myopia,but each has its advantages and limitations.