AIM:To evaluate the effect of sodium hyaluronate(SH)combined with mitomycin C(MMC) in trabeculectomy for congenital glaucoma.METHODS:Forty patients 69 eye were divided into experimental group(33 eyes) and control group(36 eyes) randomly.Trabeculectomy and MMC treatment were performed in all cases,After intermittent suture scleral flap,SH was injected into the anterior chamber and under the sutured scleral flaps in experimental group,however the control group was injected with balanced salt solution(BSS).Visual acuity,intraocular pressure(IOP),the depth of anterior chamber,the filter bleb and complications in the two groups were recorded and analyzed.All patients were followed up for 6 months.RESULTS:Postoperatively,there was no statistically significant difference in visual acuity between two groups(P>0.05).No statistically significant differences in the mean IOP between two groups were found before the operation or 1month,3 and 6 months after the operation(P>0.05).However,a statistically significant difference in the IOP of the two groups was found in the postoperative first week(P<0.05).The incidence of complications in experimental group regarding Flat anterior chamber,hyphema,choroid detachment and hypotension-induced maculopathy were significantly lower than that in control group(P<0.05).CONCLUSION:A small amount of SH injected into anterior chamber and scleral flap can reduce the postoperative complications caused by excessive percolation significantly in trabeculectomy combined with MMC for congenital glaucoma.