AIM:To evaluate the medium and long-term performance of the Verisyse iris-fixated phakic intraocular lens implantation for patients with high myopia.METHODS:Fifty-six eyes of 37 patients with high myopia who underwent the Verisyse iris-fixated phakic intraocular lens implantation from 2003 to 2006 were analyzed.The mean spherical equivalent was preoperatively(-16.62±3.70) DS,ranged from-10 to-28.5DS.Uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA),manifest refraction,corneal endothelial cell counting,intraocular pressure and complications were evaluated.RESULTS:The implantation was successful in all of 56 eyes.Compared with preoperative clinical data,UCVA,BCVA and spherical equivalent were improved significantly after surgery.The results remained stable with in 4-7 years follow-up.The changes of corneal endothelial cell counting was not significant at each time point.All corneas remained clear throughout the study.No serious complications such as progressive endothelial cell loss,persistent uveitis,glaucoma,cataract or retinal detachment were observed.CONCLUSION:Medium and long-term results demonstrate that the implantation of the Verisyse iris-fixated phakic intraocular lens for the high myopia is a stable,effective,predictable and safe method with few complications.The method is an alternative to corneal surgery for the correction of refractive errors,especially in patients with severe ametropia unsuitable for excimer laser refractive surgery.