AIM:To compare the clinical effect of ganciclovir ophthalmic gel and ganciclovir eye drops in the treatment of herpes zoster keratitis.METHODS:A total of 68 patients 68 eyes of herpes zoster keratitis were selected and divided into two groups randomly,there were 36 patients 36 eyes in ganciclovir ophthalmic gel group(observation group),32 patients 32 eyes in ganciclovir eye drops group(control group).All patients were used ganciclovir ophthalmic gel or ganciclovir eye drops six times per day,and they underwent systemic anti-viral treatment.RESULTS:The therapeutic efficiency between the observation group and the control group had no statistical difference(P>0.05).But the time of recovery in the observation group was less than that in the control group.The difference was statistically significant(P<0.05).CONCLUSION:The application of ganciclovir ophthalmic gel and ganciclovir dye drops in the treatment of herpes zoster keratitis has the same efficiency,but ganciclovir ophthalmic gel can shorten the time of recovery.