AIM:To investigate the efficacy of photodynamic therapy(PDT) on macular choroidal neovascularization(CNV) of pathologic myopia(PM).METHODS:Twenty patients 21 eyes who were diagnosed with PM were analyzed retrospectively.The changes in the best-corrected visual acuity(BCVA),fixation nature,fundus examination,FFA/ICGA and OCT were analyzed before and after PDT treatment.RESULTS:During 6 months follow-up,only 1 case was performed vitrectomy because of vitreous hemorrhage 3 months after PDT.Compared with pre-treatment of PDT,the BCVA of other patients was improved(P<0.05).Before PDT treatment,3 eyes were central fixation and 18 eyes were paracentral fixation.The fixation characteristic was not changed after PDT.3 months after PDT,FFA/ICGA showed no leakage or reduced leakage in 18 eyes(86%).In 2 eyes,the fundus remained leaky,1 eye was not followed because of vitreous hemorrhage and performing vitrectomy.In the six-month follow-up,FFA/ICGA showed no leakage or slight leakage in 19 eyes(90%) and continous leakage in 1 eye(5%).CONCLUSION:PDT can block CNV of PM completely or partly,and reduce the danger of vision loss.