AIM:To observe the effect of iris location combined with wavefront aberrations guided Epi-LASIK surgery for low to moderate myopia.METHODS:All of 100 patients 179 eyes with low to moderate myopia were randomly divided into two groups,one group of 50 patients 90 eyes received wavefront-guided joint iris location of Epi-LASIK(wavefront group) surgery;the other group of 50 patients 89 eyes received routine Epi-LASIK(control group);postoperative uncorrected visual acuity(UCVA),refraction,aberration,higher order aberrations and the satisfaction of visual quality were analyzed and correlation analysis was carried out during follow-up period.RESULTS:After 6 months,there were statistical differences(P<0.05)between wavefront group and control group patients with UCVA after surgery,preoperative best-corrected visual acuity(BCVA) and postoperative UCVA in wavefront group,preoperative BCVA and postoperative UCVA in control group;postoperative aberrations increased compared with the preoperative aberrations.Postoperative wavefront aberrations and high level aberration of wavefront group were smaller than the control group,the difference was statistically significant(P<0.05);the overall satisfaction of visual quality in wavefront group was better than control group,there were significant differences(P<0.05).CONCLUSION:The iris location combined with wavefront guided Epi-LASIK is better than the conventional Epi-LASIK in some aspects of correction of high myopia.