AIM:To study the pathological changes and clinical significance of anterior chamber angle of chronic angle-closure glaucoma patients in Kazak.METHODS:Trabecular meshwork and iris were removed by trabeculectomy,then embedded in paraffin for serial sections,hematoxylin staining and light microscope examination.RESULTS:The narrowing of trabecular meshwork and decreased endothelial cells with pigment deposition were observed by microscope examination in the trabecular meshwork.Some part of the trabecular meshwork was completely covered with pigment patch and trabecular structure could not be seen,the others were observed as trabecular meshwork fibrosis with hyaline degeneration.There was proliferation of endothelial cells in trabecular meshwork which caused lumen stenosis or occlusion.Some part of the lumen had pigment deposition with iris thinning and thickening of the iris vessel wall with hyaline.Iris stromal angiogenesis was visible in some part.CONCLUSION:The pathological damage in the anterior chamber angle is a gradual process in chronic angle-closure glaucoma patients.Early diagnosis and treatment can not only effectively prevent the damage of visual function,but also effectively prevent anterior chamber damage caused by high intraocular pressure(IOP).