AIM:To observe the therapeutic effect of manifest hypertropia cured by reinforced anterior transposition of inferior oblique muscle combined with retreat of superior rectus muscle.METHODS:All of 24 inpatients whose hypertropia were above 25△ underwent reinforced anterior transposition of inferior oblique muscle combined with retreat of superior rectus muscle,the therapeutic effect after operation was observed.RESULTS:The 24 patients were followed up for 6 months to 1 year after operation,21 cases(87.5%) were cured,3 patients(12.5%) improved,the total effective rate was 100%.CONCLUSION:The reinforced anterior transposition of inferior oblique muscle combined with retreat of superior rectus muscle is a useful method for manifest hypertropia.