·AIM:To evaluate the effect of laser in situ kerat-omileusis(LASIK)and laser epithelial keratomileusis(LASEK)on central retinal artery(CRA)blood flow.·METHODS:Clinical data of 86 patients 172 eyes underwent LASIK and 17 patients 34 eyes underwent LASEK were collected.CRA peak systolic velocity(PSV)and end diastolic velocity(EDV)in cm/s were recorded using color Doppler.Primary outcomes recorded were CRA-PSV and EDV at preoperative and postoperative 1 month,3 and 6 months;Resistance index(RI)=(PSV-EDV)/PSV;Pulsatility index(PI)=(PSV-EDV)/mV.SPSS 13.0 statistic software package was used for data analysis.·RESULTS:In LASIK group,CRA-PSV,EDV,RI and PI at various time were 9.62±0.40,9.59±0.51,9.65±0.44,9.61±0.49cm/s;3.26±0.38,3.24±0.29,3.22±0.31,3.27±0.34cm/s;0.661±0.040,0.662±0.050,0.656±0.050,0.664±0.040cm/s;1.501±0.020,1.503±0.020,1.502±0.020,1.501±0.020cm/s.In LASEK group,time-varing data were respectively 9.63±0.33,9.58±0.44,9.64±0.29,9.80±0.49cm/s;3.28±0.40,3.27±0.39,3.26±0.38,3.30±0.41cm/s;0.659±0.040,0.658±0.040,0.661±0.030,0.663±0.030cm/s;1.502±0.020,1.501±0.020,1.503±0.020,1.501±0.020cm/s.There were no significant differences between pre-and postoperation at various times.·CONCLUSION:During LASIK and LASEK,impact force and vacuum suction have no adverse effect on CRA blood flow.·