·AIM:To explore the effect of paracentesis of anterior chamber combined laser peripheral iridectomy(LPI)in treatment of acute attack of primary angle-closure glaucoma.·METHODS:Totally 36 cases 40 eyes of acute attack of primary angle-closure glaucoma were divided into two groups.The combined therapy group was treated by paracentesis of anterior chamber combined LPI,the control group was treated by medicine that could decrease IOP,then intraocular pressure(IOP),anterior chamber angle and the percentage of acute attack stopping and trabeculectomy were observed.·RESULTS:The rate of acute attack stopping was 89% in paracentesis of anterior chamber combined LPI group,and 38%(P <0.05)in control group;In therapy group the rate of trabeculectomy was 32%,in control group it was 76%(P <0.05).·CONCLUSION:The paracentesis of anterior chamber combined LPI have show it’s better efficacy in patients of acute attack of primary angle-closure glaucoma.It can quickly open the closed angle,control IOP.So it can increase the percentage of acute attack stopping and decrease the rate of trabeculectomy.·