·AIM:To observe the comparision of postoperative complications between with and without Ando hole in vitrectomy for diabetic retinopathy.·METHODS:The patients who were treated with vitrectomy surgery combined with PEA and intraocular lens(IOL)implantation were retrospectively analyzed,including 90 cases(95 eyes)with Ando hole and 92 cases(98 eyes)without Ando hole in department of ophthalmology of the first hospital of China Medical University.The incidences of postoperative complications-posterior synechia of the iris,IOP rising caused by atretopsia were observed.·RESULTS:There were 15 eyes with atretopsia and 12 eyes with IOP raising in control group.There were 14 eyes with atretopsia and none with IOP rising in control group.There were no significant differences in the incidences of atretopsia and posterior synechia of the iris between the two groups,but the incidences of IOP rising were significantly different between the two groups.·CONCLUSION:Ando hole can avoid IOP rising caused by atretopsia in vitrectomy for diabetic retinopathy.·