·AIM:To investigate the clinical effect of soft corneal contact lens for perforated corneal ulcer.·METHODS:Twenty-four cases 24 eyes with perforated corneal ulcer were treated by soft corneal contact lens,in which fourteen cases 14 eyes were with bacterial corneal ulcer,eight cases 8 eyes were with viral corneal ulcer,two cases 2 eyes were with fungual corneal ulcer.Combination therapy was chosen according to different causes of disease.The soft corneal contact lens was cleaned after one week,changed after three weeks until ulcer healed.·RESULTS:In 24 cases 24 eyes of perforated corneal ulceration patients,anterior chamber was formed after 1-2 days,corneal epithelium covered,corneal stromal layer fiber mesh scaffolds formed after 5-10 days,20-32 days later corneal ulcer healed perforated area closed well.Vision had improved with different degrees.·CONCLUSION:It is a safe and effective adjunctive therapy to cure perforated corneal ulceration with soft corneal contact lens.·