AIM:To discuss the pathogen, clinical manifestation and the treatment of the intraoperative floppy-iris syndrome(IFIS)which occurs in the process of cataract surgery.METHODS: Totally 489 operation inpatients (558 eyes) with extracapsular cataract extraction (ECCE) and phacoemulsification in our hospital in 2008-2009 were reviewed. We analyzed the holistic and local drug-use state of patients preoperatively and surveyed the changes in the iris and the pupil of these operation on inpatients of IFIS when we injected adrenalin hydrochloride and viscoat in anterior chamber or used iris hooks and iris dilator rings in operations.RESULTS: In 2008, 9 cases attacked by IFIS in 236 operation inpatients of cataract surgery (279 eyes), and in 2009, 2 cases in 2009 in 253 operation inpatients of cataract surgery (279 eyes). The incidence rate difference(IRD) of IFIS in two years had clinical significance (P<0.05).CONCLUSION: The incidence of IFIS in cataract surgery is related to the using of α1 antitrypsin deficiency. Taking preventive action can reduce the morbidity for related cases before the operation. In operations, for the case of prolapse of iris and the contraction of pupil, injecting diluted adrenalin hydrochloride and viscoat in anterior chamber or using iris hooks and iris dilator rings when performed can prevent the tendency of prolapse of the iris through the incision basically, ameliorate the level of the contraction of pupil to a certain extent and reduce the incidence of the complication.