Dry eye is multifactorial disease of tear film and ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Anti-inflammatory therapy has been one of the key components in the treatment of dry eye. Non-steroidal anti-inflammatory drugs (NSAIDs) are being introduced into the treatment of dry eye, with evident anti-inflammatory action and less side-effect. In this review, we summarize recent data regarding the application of NSAIDs in the treatment of dry eye.