AIM:To observe the treatment effectiveness of nasolacrimal duct obstruction by modified silicone tube retrograde intubation. METHODS:The outpatients diagnosed with nasolacrimal duct obstruction and chronic dacryocystitis were 68 cases (74 eyes).The procedure of retrograde intubation was performed in local anesthesia.The situation of lacrimal duct,epiphora, silicone tube location and cleanliness were observed after intubation. RESULTS:The lacrimal duct system was able to be irrigaetd one week after the operation. More than one year follow-up showed the cure rate was 94.6% after the removal of silicone tube. CONCLUSION:Modified silicone tube retrograde intubation for treatment of nasolacrimal duct obstruction is safe, minimally invasive, less time, less bleeding and good effect.