AIM:To investigate the related risk factors associated with diabetic retinopathy(DR).METHODS:DR patients who were hospitalized in our hospital from September 2009 to February 2011 were selected.The retrospective study included 83 cases of clinical data about DR patients.A number of disease-related risk factors of DR were detected through comparison between the two groups,univariate analysis and multivariate analysis.RESULTS:Difference of the related factors such as duration of diabetes mellitus(DM),glycated hemoglobin(HbAlc),IOP,and central retinal artery-resistance index(CRA-RI) between the non-proliferative diabetic retinopathy group(NPDR group) and proliferative diabetic retinopathy group(PDR groups) had statistical significance.Univariate analysis of the risk factors of DR showed:the risk factors such as CRA-RI,IOP,duration of DM,HbAlc and systolic blood pressure(SBP) correlated with the occurrence and development of DR.Logistic regression analysis of the risk factors of DR showed:CRA-RI,HbA1c and SBP finally had statistical significance and correlated with the occurrence and development of DR.CONCLUSION:With the prolonged course and severity of the disease in PDR group,the higher the HbAlc was,the higher CRA-RI became,and the lower IOP was when compared with the control group(NPDR group).According to the factors in this study,the main correlation risk factors of DR were CRA-RI,HbAlc and SBP,duration of DM also influenced the occurrence and development of DR in a certain extent.