AIM:To evaluate the clinical effect of oculyzer-guided laser in situ keratomileusis(LASIK) and conventional LASIK on the correction of hyperopia and hypermetropic astigmatism.METHODS:Totally 55 patients(110 eyes) were randomly divided into two groups.One group of 25 patients(50 eyes) were performed with oculyzer-guided customized LASIK,the other group of 30 patients(60 eyes) with conventional LASIK.Postoperative uncorrected visual acuity(UCVA),refraction and decentered ablation complication were observed.RESULTS:The postoperative visual acuity of the two groups both improved significantly and the postoperative refraction regressed in varying degrees.In oculyzer-guided customized LASIK group,the postoperative UCVA was better and the refraction at 6 months after operation was more reliable.There was statistical difference between the two groups(P<0.05).The incidence rate of postoperative decentered ablation in oculyzer-guided customized LASIK group was obviously less than that in conventional LASIK group and presented significantly statistical difference(P<0.01).CONCLUSION:Oculyzer-guided customized LASIK for hyperopia showed better visual acuity,less postoperative complication and was predictable.