AIM:To determine the growth rule and trendency of the glaucoma literature by bibliometric analysis.METHODS:Logging in www.ncbi.nlm.nih.gov/PubMed,"glaucoma" was used to retrieve from 1858-01-01 to 2010-12-31 literature volume,meanwhile,literature volume(amount of every five years for a time period),Chinese collected,language distribution,document type distribution,journal distribution,and related research content in a database were retrieved,according to the theory of increasing law of the literature,the data retrieved were analysed.RESULTS:From 1858 to 2010,PubMed database included 45514 articles of glaucoma literature,all the cumulative literature volume was increasing year by year,the equation was approximate line(Y =579.34X-568.38,R2=0.882).1858-2010 glaucoma literature was dominated in English(71.50%),literature volume published in Chinese was ranked in the twelveth(0.31%),PubMed began to include Chinese glaucoma literature in 2006,which increased dramatically after 2009 years.According to the PubMed database literature types,it included Clinical Trial(2947 articles),Editorial(648 articles),Letter(1727 articles),Meta-Analysis(81 articles),Practice Guideline(15 articles),Randomized Controlled Trial(1787),Review(3633 articles),Others(34678 articles);glaucoma literature included according to Journal Groups were divided into Core Clinical Journals(625 articles),Dental Journals(5 articles),Nursing Journals(42 articles),Others(44844 articles);37194 articles were related with Humans,Animals related literatures were 4223 articles,Others 4099.Nineteen kinds of glaucoma core journal in PubMed included 20526 articles(45.10% collected literature).CONCLUSION:The amount of research articles about glaucoma shows ascendant trend,indicating that glaucoma is still a hot tissue,the main factors of the influence on glaucoma literature growth is the environmental conditions of subject development.