AIM:To observe treatment efficacy of wearing orthokeratology lens for juvenile myopia.METHODS:Seventy-six cases(152 eyes) of myopia,with age of 8-15 years old and the average spherical equivalent degree-3.92±1.13D,wore orthokeratology lens,according to the fitting program of orthokeratology,at night for 8-10 hours.They were followed up at 1 week,1 month,3,6 months,1 year,2 years after wearing glasses and observed with uncorrected visual acuity(UCVA),refraction,corneal curvature,axial length,slit-lamp examination with or without complications.RESULTS:One week,1 month,3,6 months,1 year,2 years after wearing glasses,UCVA increased from 0.15±0.12 before wearing glasses to 0.60±0.12,0.80±0.10,0.90±0.18,0.88±0.16,0.90±0.15,0.89±0.18,the differences were statistically significant(P<0.01);Corneal curvature flattened and decreased by 2.31±0.82,2.41±0.91,2.12±0.75,2.21±1.01,2.51±1.12,2.46±0.98D,differences were statistically significant(all P<0.001);1 year after wearing glasses,axial length increased by 0.13±0.11mm than that before wearing glasses,2 years after wearing glasses,the axial length increased by 0.25±0.17mm than that before wearing glasses,and there was no statistically significant difference;Compared myopia degree after full 2 years of wearing glasses and 1 week of stopped wearing with that before wearing glasses,myopia degree increased less with average annual 0.25±0.11D.After wearing glasses,a small number of patients with punctate corneal epithelial exfoliation,ghosting,conjunctivitis,etc.,could be restored after treatment.CONCLUSION:Orthokeratology treatment of juvenile myopia is effective and safe,which can control the development of myopia.