AIM:To evaluate the effect of diode laser transscleral cyclophotocoagulation(DL Tscpc) for refractory glaucoma.METHODS:Retrospective analysis was made in 55 patients(56 eyes) with refractory glaucoma who treated by DL Tscpc.Intraocular pressure(IOP),visual acuity,ocular symptoms and complications were observed after DL Tscpc.Patients were followed up over 3 months.RESULTS:Mean preoperative IOP was 53.5±18.7mmHg which was significantly different from the final follow-up mean IOP 19.4±9.6mmHg(P<0.01).Postoperative visual acuity remained unchanged in 44 eyes;improved in 2 eyes and decreased in 10 eyes.The pain sense disappeared or remarkably relieved.The main complications included uveitis and hyphema,etc.CONCLUSION:DL Tscpc is a simple,safe and effective therapy for eyes with refractory glaucoma.