AIM:To research retina and Bruch’s membrane of apolipoprotein E-deficient(ApoE-/-) mice effected by dyslipidemia.METHODS:Twenty-four 2-month-old ApoE-/-mice and 24 C57BL mice were randomly divided into group of normal chow and group of high fat chow,12 mice each group.Animals were killed four months later and plasma total cholesterol(TG) levels were determined.Light microscopy and transmission electron microscopy were used to observe retina and Bruch membrane.RESULTS:The plasma TG of the group of 6-month-old ApoE-/-mice high fat chow(HF) was significantly higher than that of control group(P<0.05).The thickness of outer nuclear layer(ONL)and retinal pigment epithelium(RPE) was statistically lower than that of control group(P<0.05),while the thickness of Bruch membrane was significantly higher than the control group(P<0.05).CONCLUSION:The pathology change of photoreceptor,RPE and Bruch membrane was similar to the change of early age-related macular degeneration(AMD).