Inflammation can promote the growth of corneal neovascularization.p38 mitogen-activated protein kinase signal transduction pathway may play an important role in the progress of inflammation by controlling the expressions of IL-1β,IL-6,TNF-α and so on.p38 inhibitors not only suppress the expressions of inflammatory mediators,but also block their activities.p38 inhibitors greatly curb the progress of inflammations.It is a new strategy to explore the developing mechanism of corneal neovascularization through the pathway of p38 signal transduction.