AIM:To research high risk factors for promoting endophthalmitis after open ocular injuries.METHODS:Totally 312 cases(315 eyes) with open ocular injuries were recalled and analyzed.The different factors working in promoting endophthalmitis after open ocular injuries were analyzed.RESULTS:Vitreum foreign body,rupture of post-capsule membrane and stab by slightness object significantly increased the risk of endophthalmitis,and it was statistically significant.Delay in primary repair more than 24 hours also increased the risk of endophthalmitis after open ocular injuries,but was not statistically significant.The length of the wound increased didn’t increase the risk of endophthalmitis after open ocular injuries.CONCLUSION:Vitreum foreign body,rupture of post-capsule membrane and stab by slightness object are the high risk factors for promoting endophthalmitis after open ocular injuries.Based on the wound repaired in time,the length of the wound increased didn’t increase the risk of endophthalmitis after open ocular injuries.