AIM:To investigate the effect of punctum plugs relieved the dry eye symptoms at the early stage after Laser in situ keratomileusis(LASIK).METHODS:Fifty-four patients(108 eyes) were treated with LASIK in our hospital.54 eyes of 27 patients received punctum plugs as treatment randomly 2 days after surgery.The other patients used artificial tear instead.Schirmer Ⅰ test(SⅠt),tear break-up time(BUT) and fluorescent staining(FL) were measured 2 weeks after surgery.RESULTS:The SⅠt in punctum plugs group was 11.90±4.20mm/5min,while 10.85±3.42mm/5min,in eye drop group.The BUT were 13.12±2.58s and 11.67±3.29s in punctum plugs group and eye drop group respectively.The FL were 6.23±1.12 and 5.42±2.10.CONCLUSION:Our results showed that there was no difference between punctum plugs group and eye drop group to relieve the dry eye symptoms at the early stage after LASIK.